abstract：:Previous studies in our laboratory identified retinoid-induced defects that are mediated by RAR-RXR heterodimerization using interaction of synthetic ligands selective for the retinoid receptors RAR and RXR in mice (Elmazar et al. 1997, Toxicol Appl Pharmacol 146:21-28; Elmazar et al. 2001, Toxicol Appl Pharmacol 170:...

journal_title：Archives of toxicology

authors： Elmazar MM,Nau H

更新日期：2004-11-01 00:00:00

abstract：:Rats were exposed to black tea (2.5% w/v) as their sole drinking liquid for either 1 day or 1 month, while controls were maintained on water. After this treatment period, all animals received a single oral dose IQ (2-amino-3-methylimidazo-[4,5-f]quinoline), and urine was collected for 48 h. Mutagenic activity of the u...

journal_title：Archives of toxicology

authors： Yoxall VR,Parker DA,Kentish PA,Ioannides C

更新日期：2004-08-01 00:00:00

abstract：:Heat shock proteins (HSPs) are a group of proteins that are rapidly induced in response to physiological stress, including hyperthermia and exposure to toxicants. Thus they may provide a useful index of toxicity in in vitro systems for screening for toxicity. We have recently developed a rat nasal explant system for i...

journal_title：Archives of toxicology

authors： Simpson SA,Alexander DJ,Reed CJ

更新日期：2004-06-01 00:00:00

abstract：:Whether pregnancy-induced immunosuppression when combined with exposure to 2,3,7,8-tetrachlorodibenzo- p-dioxin (TCDD) could exacerbate immunotoxicity has not been previously investigated. The current study evaluated the immune status of C57BL/6 pregnant and virgin mice following exposure to TCDD. To this end, syngene...

journal_title：Archives of toxicology

authors： Camacho IA,Nagarkatti M,Nagarkatti PS

更新日期：2004-05-01 00:00:00

abstract：:Previous studies have shown the antidotal efficacy of topical iodine at 15 and 30 min post-exposure to sulfur mustard (SM). Here we demonstrate efficacy at longer intervals (20, 30, 45, and 60 min, respectively, for data) using an improved topical povidone-iodine preparation termed N66, which contains steroidal and no...

journal_title：Archives of toxicology

authors： Wormser U,Sintov A,Brodsky B,Casillas RP,Nyska A

更新日期：2004-03-01 00:00:00

abstract：:The aim of this study was to investigate the electrophilic tissue burden (ETB) formation, assessed as covalent binding of the ultimate carcinogen benzo( a)pyrene diolepoxide (BaPDE) with cellular proteins, in liver, lung and heart, as well as with haemoglobin (Hb) following repeated exposure to binary mixtures of benz...

journal_title：Archives of toxicology

authors： Tzekova A,Leroux S,Viau C

更新日期：2004-02-01 00:00:00

abstract：:Garenoxacin is a des-F(6)-quinolone with a broad antibacterial spectrum, which has previously been shown to exhibit low chondrotoxicity in juvenile dogs compared with several other quinolones. A study was performed to determine whether the low chondrotoxicity observed in immature rats following garenoxacin treatment c...

journal_title：Archives of toxicology

authors： Kastner M,Rahm U,Baumann-Wilschke I,Bello A,Stahlmann R

更新日期：2004-02-01 00:00:00

abstract：:Doppler and M-mode echocardiography (EC) were used to investigate the effects of minoxidil on the cardiac function of the dog and potentially to clarify the pathogenesis of cardiac lesions, in particular the necrotic lesion in the left ventricle and the haemorrhagic lesion in the right atrium. Groups of three dogs wer...

journal_title：Archives of toxicology

authors： Hanton G,Gautier M,Bonnet P

更新日期：2004-01-01 00:00:00

abstract：:Okadaic acid (OA) is produced by several types of dinoflagellates (marine plankton) and has been implicated as the causative agent of diarrhetic shellfish syndrome. Previous studies have shown that okadaic acid is a tumor promoter and a specific potent inhibitor of protein phosphatases and protein synthesis. These eff...

journal_title：Archives of toxicology

authors： Traoré A,Baudrimont I,Dano S,Sanni A,Larondelle Y,Schneider YJ,Creppy EE

更新日期：2003-11-01 00:00:00

abstract：:The flavonol quercetin shows a wide range of effects in biological systems. We investigated whether quercetin exerts its proposed antioxidant properties via the antioxidant enzyme system. Quercetin in a concentration range from 5 to 100 microM decreased manganese superoxide dismutase, glutathione peroxidase, and coppe...

journal_title：Archives of toxicology

authors： Röhrdanz E,Bittner A,Tran-Thi QH,Kahl R

更新日期：2003-09-01 00:00:00

abstract：:The studies presented were designed to investigate the effects of cytochrome P450 inhibition on tetrahydrofuran-induced hepatocellular proliferation in female B6C3F(1) mice. Groups of female B6C3F(1) mice were exposed to dynamic atmospheres containing tetrahydrofuran (THF) concentrations of 0, 5,400 or 15,000 mg/m(3) ...

journal_title：Archives of toxicology

authors： van Ravenzwaay B,Gamer AO,Leibold E,Kaufmann W

更新日期：2003-08-01 00:00:00

abstract：:2,3,7,8-Tetrachlorodibenzo- p-dioxin (TCDD) is known to influence vitamin A homeostasis. In order to investigate the mechanism behind this retinoid disruption, male Sprague-Dawley rats were exposed to TCDD at doses ranging from 0.1 to 100 micro g/kg body weight, and were killed 3 days after exposure. Additional groups...

journal_title：Archives of toxicology

authors： Schmidt CK,Hoegberg P,Fletcher N,Nilsson CB,Trossvik C,Håkansson H,Nau H

更新日期：2003-07-01 00:00:00

abstract：:The effects of dicamba, a widely used broad-leaf herbicide, on rat liver mitochondrial bioenergetic activities were examined. The results obtained for state 4 respiration indicate not only an uncoupling effect, the result of an increase on the permeability of inner mitochondria membrane to protons, but also a strong i...

journal_title：Archives of toxicology

authors： Peixoto F,Vicente JA,Madeira VM

更新日期：2003-07-01 00:00:00

abstract：:Intake of inorganic arsenic is known to cause vascular diseases as well as skin lesions and cancer in humans. We investigated the differences in cytotoxicity, uptake rate of arsenic, and gene expression of antioxidative enzymes between arsenite (As(3+))- and arsenate (As(5+))-exposed rat heart microvessel endothelial ...

journal_title：Archives of toxicology

authors： Hirano S,Cui X,Li S,Kanno S,Kobayashi Y,Hayakawa T,Shraim A

更新日期：2003-06-01 00:00:00

abstract：:Long-term exposure of rats to cadmium (Cd) resulted in a marked suppression of erythropoietin (Epo) mRNA expression in the kidneys and the development of severe anemia. A recent report revealed that Cd inhibited hypoxia-inducible factor 1 (HIF-1) binding activity and Epo mRNA expression and protein production. However...

journal_title：Archives of toxicology

authors： Obara N,Imagawa S,Nakano Y,Suzuki N,Yamamoto M,Nagasawa T

更新日期：2003-05-01 00:00:00

abstract：:Dibromoacetonitrile (DBAN) is a disinfection byproduct of chlorination of drinking water. Epidemiological studies indicate that it might present a potential hazard to human health. The present work provides evidence for DBAN activation to cyanide (CN(-)) by the hypoxanthine (HX)/xanthine oxidase (XO)/iron (Fe) system ...

journal_title：Archives of toxicology

authors： Mohamadin AM,Abdel-Naim AB

更新日期：2003-02-01 00:00:00

abstract：:Hibiscus protocatechuic acid (PCA), a phenolic compound found in the dried flowers of Hibiscus sabdariffa L. (Malvaceae), was demonstrated to have an antioxidant effect in vitro and in vivo, and an antitumor property in our previous study. In the present study, we used lipopolysaccharide (LPS, an endotoxin) to induce ...

journal_title：Archives of toxicology

authors： Lin WL,Hsieh YJ,Chou FP,Wang CJ,Cheng MT,Tseng TH

更新日期：2003-01-01 00:00:00

abstract：:Berberine, a main protoberberine component of Coptidis Rhizoma, was studied for the mechanism of its inhibitory effects on the tert-butyl hydroperoxide (t-BHP)-induced cytotoxicity and lipid peroxidation in rat liver. In the preliminary study, berberine expressed an antioxidant property by its capacity for quenching t...

journal_title：Archives of toxicology

authors： Hwang JM,Wang CJ,Chou FP,Tseng TH,Hsieh YS,Lin WL,Chu CY

更新日期：2002-11-01 00:00:00

abstract：:Standard treatment of poisoning by organophosphates (OP) includes the administration of an antimuscarinic agent, e.g. atropine, and of an acetylcholinesterase (AChE) reactivator (oxime). The presently available oximes, obidoxime and pralidoxime (2-PAM), are considered to be insufficient for highly toxic OPs, e.g. sari...

journal_title：Archives of toxicology

authors： Worek F,Reiter G,Eyer P,Szinicz L

更新日期：2002-09-01 00:00:00

abstract：:The deleterious effect of lead has been attributed to lead-induced oxidative stress with the consequence of lipid peroxidation. The present study was designed to investigate the combined effect of DL-alpha-lipoic acid (LA) and meso-2,3-dimercaptosuccinic acid (DMSA) on lead-induced peroxidative damages in rat kidney. ...

journal_title：Archives of toxicology

authors： Sivaprasad R,Nagaraj M,Varalakshmi P

更新日期：2002-08-01 00:00:00

abstract：:We have used the minipig as a prospective animal model for human risk characterization to study primary biochemical alterations upon oral contaminant intake. The effects of three orally administered soils containing polycyclic aromatic hydrocarbons (PAH) on the expression pattern of the cytochrome P450 enzyme CYP1A1 i...

journal_title：Archives of toxicology

authors： Roos PH,Tschirbs S,Welge P,Hack A,Theegarten D,Mogilevski G,Wilhelm M

更新日期：2002-06-01 00:00:00

abstract：:There is considerable epidemiological evidence that workers exposed to carbon disulfide (CS2) develop premature atherosclerosis leading to increased rates of coronary heart disease (CHD), but mechanisms underlying this association remain obscure. The present study documents that occupational exposure to CS2 modifies t...

journal_title：Archives of toxicology

authors： Wronska-Nofer T,Chojnowska-Jezierska J,Nofer JR,Halatek T,Wisniewska-Knypl J

更新日期：2002-04-01 00:00:00

abstract：:The aim was to study the long-term response in the olfactory mucosa of NMRI mice after exposure to the olfactory toxicants dichlobenil (a herbicide) or methimazole (an antithyroid drug). Three and six months after exposure to dichlobenil (2x or 1 x 25 mg/kg i.p.), the dorsomedial part of the olfactory region showed a ...

journal_title：Archives of toxicology

authors： Bergman U,Ostergren A,Gustafson AL,Brittebo B

更新日期：2002-03-01 00:00:00

abstract：:The object of this study was to compare the relative sensitivity of markers of exposure and effects in the lung of rats exposed to polymeric diphenyl-methane-4,4'-diisocyanate (pMDI) aerosol. Rats were repeatedly exposed to 12.9 mg pMDI/m(3) (6 h/day, 5 days/week for 14 days; exposure was from days 0--17 followed by a...

journal_title：Archives of toxicology

authors： Pauluhn J

更新日期：2002-02-01 00:00:00

abstract：:Chlorpyrifos (CPF) is a widely used organophosphorus pesticide. Earlier work from our laboratory and others has demonstrated that the sensitivity to CPF exposure changes markedly during maturation. A number of studies suggest that in addition to inhibiting acetylcholinesterase (AChE), CPF oxon may also interact direct...

journal_title：Archives of toxicology

authors： Zhang H,Liu J,Pope CN

更新日期：2002-01-01 00:00:00

abstract：:In a previous study, we showed that bisphenol A (BPA) had oestrogen-like effects in bird embryos, causing malformations of the oviducts in Japanese quail (Coturnix japonica) and feminisation of the left testis in chicken (Gallus domesticus). In this study, uptake and distribution of BPA and tetrabromobisphenol A (TBBP...

journal_title：Archives of toxicology

authors： Halldin K,Berg C,Bergman A,Brandt I,Brunström B

更新日期：2001-12-01 00:00:00

abstract：:The uncertainties that surround the methods used for risk assessment of exposure to carcinogens have been highlighted by a recent document advocating an approach based on the T25 dose (the dose giving a 25% incidence of cancer in an appropriately designed animal experiment). This method relies on derivation of the T25...

journal_title：Archives of toxicology

authors： Roberts RA,Crump KS,Lutz WK,Wiegand HJ,Williams GM,Harrison PT,Purchase IF

更新日期：2001-11-01 00:00:00

abstract：:The toxicity of amphetamines is conditioned by a complex array of mechanisms, involving the increase of neurotransmission (e.g. leading to hyperthermia) and enzymatic and non-enzymatic oxidation of amphetamines and biogenic amines. Considering that all these processes may increase the generation of hydrogen peroxide (...

journal_title：Archives of toxicology

authors： Carvalho F,Duarte JA,Neuparth MJ,Carmo H,Fernandes E,Remião F,Bastos ML

更新日期：2001-10-01 00:00:00

abstract：:To examine the demethylation reaction of methylmercury (MeHg) in rat liver, slices prepared from MeHg-treated rats were incubated in L-15 medium under 95% O2/5% CO2 atmosphere. During the incubation, the amount of inorganic Hg in the slices markedly increased in a time-dependent manner, although the concentration of t...

journal_title：Archives of toxicology

authors： Yasutake A,Hirayama K

更新日期：2001-09-01 00:00:00

abstract：:Interactions between chemicals in a mixture and interactions of mixture components with the skin can significantly alter the rate and extent of percutaneous absorption, as well as the cutaneous disposition of a topically applied chemical. The predictive ability of dermal absorption models, and consequently the dermal ...

journal_title：Archives of toxicology

authors： Riviere JE,Qiao G,Baynes RE,Brooks JD,Mumtaz M

更新日期：2001-08-01 00:00:00

abstract：:2,2-Dichloro-1,1,1-trifluoroethane (HCFC-123) has been developed as a substitute for ozone-depleting chlorofluorocarbons (CFCs). It is a structural analogue of halothane and similarities in the metabolic pathways and liver toxicity of both compounds have been described. The present study was initiated after an acciden...

journal_title：Archives of toxicology

authors： Hoet P,Buchet JP,Sempoux C,Nomiyama T,Rahier J,Lison D

更新日期：2001-07-01 00:00:00

abstract：:Previous studies indicate that benzanthrone, an anthraquinone dye intermediate, caused significant depletion of ascorbic acid (AsA). In this investigation the effect of benzanthrone on the status of different forms of AsA and other bio-antioxidants such as glutathione (GSH) was studied. Oral administration of benzanth...

journal_title：Archives of toxicology

authors： Dwivedi N,Das M,Khanna SK

更新日期：2001-06-01 00:00:00

abstract：:This study examined the effect of tamoxifen, an anti-breast cancer drug, on Ca2+ handling in bladder female transitional cancer cells. Changes in cytosolic free Ca2+ levels were recorded by using the Ca2+-sensitive dye fura-2. In a dose-dependent manner, tamoxifen induced intracellular free Ca2+ concentrations ([Ca2+]...

journal_title：Archives of toxicology

authors： Chang HT,Huang JK,Wang JL,Cheng JS,Lee KC,Lo YK,Lin MC,Tang KY,Jan CR

更新日期：2001-05-01 00:00:00

abstract：:A series of experiments was set up to elucidate the effects of pollution on marine and estuarine fish health, since the European flounder (Platichthys flesus) has shown a relatively high prevalence of (pre)neoplastic liver lesions and lymphocystis virus disease in Dutch coastal and estuarine waters. The hypothesis of ...

journal_title：Archives of toxicology

authors： Grinwis GC,van den Brandhof EJ,Engelsma MY,Kuiper RV,Vaal MA,Vethaak AD,Wester PW,Vos JG

更新日期：2001-04-01 00:00:00

abstract：:Male F344/DuCrj (Fischer) rats were given bisphenol A (BPA) in the diet at levels of 0 (control), 0.25, 0.50 and 1.00%, equivalent to 0, 235, 466 and 950 mg/kg per day, respectively, for 44 days. Body weight gains were depressed dose-dependently in BPA-treated rats, and those of 0.50 and 1.00% groups were significant....

journal_title：Archives of toxicology

authors： Takahashi O,Oishi S

更新日期：2001-03-01 00:00:00

abstract：:Shaking behavior, so-called wet dog shakes (WDS), in rats is characteristic behavior indicating morphine abstinence in morphine-dependence and central excitation in relation to seizures elicited by chemicals or electrical stimulation. We have found that paraquat (PQ), a nonselective herbicide, administered systemicall...

journal_title：Archives of toxicology

authors： Hara S,Mukai T,Kurosaki K,Kuriiwa F,Yanase T,Kano S,Endo T

更新日期：2001-02-01 00:00:00

abstract：:The aim of this study was to investigate the genotoxic potential of DNA adducts and to compare DNA adduct levels and patterns in petroleum vacuum distillates, coal tar distillate, bitumen fume condensates, and related substances that have a wide range of boiling temperatures. An in vitro assay was used for DNA adduct ...

journal_title：Archives of toxicology

authors： Akkineni LK,Zeisig M,Baranczewski P,Ekström LG,Möller L

更新日期：2001-01-01 00:00:00

abstract：:Acute toxicity of bis (tributyltin) oxide in the sweat glands in the rat footpad was investigated by electron microscopy and an energy-dispersive X-ray microanalyzer. Male Wistar rats received an intramuscular injection of 0.5 ml/kg bis (tributyltin) oxide. After 6-8 h, swelling of mitochondria appeared in the secreto...

journal_title：Archives of toxicology

authors： Yamamoto O,Doi Y,Kudo H,Yoshizuka M,Fujimoto S

更新日期：2000-12-01 00:00:00

abstract：:The first step in the oxidative metabolism of cocaine is N-demethylation to norcocaine, which is further N-hydroxylated to more toxic N-hydroxynorcocaine. In this study we examined the kinetics of norcocaine N-hydroxylation mediated by cytochrome P450 (CYP) in mouse and human liver microsomes. N-hydroxynorcocaine was ...

journal_title：Archives of toxicology

authors： Pellinen P,Kulmala L,Konttila J,Auriola S,Pasanen M,Juvonen R

更新日期：2000-11-01 00:00:00

abstract：:Cytotoxic effects of cyclophosphamide (CPA), paclitaxel (PCT), and docetaxel (DTX) and their modulation by cytochrome P450 (CYP) metabolism were studied by incubating cell lines L929 and P388D1 with or without rat liver microsomes. The microsomes themselves were not cytotoxic. P388D1 cells were more sensitive to CPA, ...

journal_title：Archives of toxicology

authors： Gut I,Danielová V,Holubová J,Soucek P,Klucková H

更新日期：2000-10-01 00:00:00